2-Methoxyethanol → HCID 22478200, compound

HRID 2182533Notes

Reaction equation

HRID 2182533 reaction equation
[Na].[CH3:2][O:3][CH2:4][CH2:5][OH:6].Cl.Cl[C:9]1[CH:18]=[C:17]2[C:12]([C:13]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=3[F:27])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[N+:28]([O-:30])=[O:29]>C(O)(=O)C.O>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([NH:19][C:13]2[C:12]3[C:17](=[CH:18][CH:9]=[C:10]([N+:28]([O-:30])=[O:29])[CH:11]=3)[N:16]([O:6][CH2:5][CH2:4][O:3][CH3:2])[CH2:15][N:14]=2)=[C:21]([F:27])[CH:22]=1

Participants

6

Reactant 3

HCID 80192-MethoxyethanolHCID 5360545SodiumHCID 224782507-Chloro-4-(4-chloro-2-fluoroanilino)-6-nitroquinazoline hydrochloride

Product 1

HCID 22478200HCID 22478200, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Sodium (148 mg, 6.4 mmol) was added to 2-methoxyethanol (10 ml), the mixture stirred for 15 minutes to give a complete solution and the volatiles removed by evaporation. The residue was dissolved in DMSO (5 ml) and 7-chloro-4-(4-chloro-2-fluoroanilino)-6 nitroquinazoline hydrochloride (500 mg, 1.3 mmol) was added. The mixture was stirred at ambient temperature for 18 hours then diluted with a solution of acetic acid (1 ml) in water (20 ml). The resulting precipitate was collected by filtration, washed with water, dried and purified by column chromatography eluting with methylene chloride/methanol (96/4). The purified product was recrystallized from methylene chloride/isohexane to give 4-(4-chloro-2-fluoroanilino)-1-(2-methoxyethoxy)-6-nitroquinazoline (304 mg, 60%) as a yellow solid.

Workup

  1. customto give a complete solution
  2. customthe volatiles removed by evaporation
  3. dissolutionThe residue was dissolved in DMSO (5 ml)
  4. stirringThe mixture was stirred at ambient temperature for 18 hours
  5. filtrationThe resulting precipitate was collected by filtration
  6. washwashed with water
  7. customdried
  8. custompurified by column chromatography
  9. washeluting with methylene chloride/methanol (96/4)
  10. customThe purified product was recrystallized from methylene chloride/isohexane

Sources & evidence

ORD record
ord-4f010e014e6d4044874d0312236ac532
Source dataset
uspto-grants-2005_05
Patent number
US06897210B2

Reaction notes

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