反应详情

A mixture of 21 (0.63 g; 2.6 mmol), 48% aqueous hydrobromic acid (15 mL) and acetic acid (12 mL) was stirred under nitrogen at reflux overnight. The suspension was decanted from dark solid and evaporated. The residue was taken up in boiling dichloromethane (three lots of 50 mL), filtered hot and evaporated giving 22 as pale brown solid (0.290 g):

1. temperatureat reflux overnight
2. customThe suspension was decanted from dark solid
3. customevaporated
4. filtrationfiltered hot
5. customevaporated