Sodium ethanethiolate → 7-(3-(Ethylthio)propoxy)6-methoxyquinazoline

HRID 2182547Notes

Reaction equation

HRID 2182547 reaction equation
[CH2:1]([S-:3])[CH3:2].[Na+].[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][N:11]=[CH:10]2>CN(C=O)C.O>[CH2:1]([S:3][CH2:15][CH2:16][CH2:7][O:6][C:16]1[CH:15]=[C:14]2[C:9]([CH:10]=[N:11][CH:12]=[N:13]2)=[CH:8][C:7]=1[O:6][CH3:5])[CH3:2]

Participants

5

Reactant 2

HCID 4459711Sodium ethanethiolateHCID 131268876-Methoxyquinazoline

Product 1

HCID 865864637-(3-(Ethylthio)propoxy)6-methoxyquinazolineYield 108.4%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of sodium ethanethiolate (120 mg, 1.5 mmol) and 4-(4-chloro-2-fluoroanilino)-73chloropropoxy)6-methoxyquinazoline (227 mg, 0.57 mmol) in DMF (10 ml) was stirred and heated at 70° C. for 3 hours. The reaction mixture was allowed to cool, was diluted with water and extracted with ethyl acetate (3×75 ml). The extracts were combined, washed with water (×2), and then brine, and dried (MgSO4). The solvent was removed by evaporation and the residue was recrystallised from ethyl acetate/hexane to give 4-chloro-2-fuoroanilino)-7-(3-(ethylthio)propoxy)6-methoxyquinazoline (86 mg, 40%).

Workup

  1. temperatureto cool
  2. extractionextracted with ethyl acetate (3×75 ml)
  3. washwashed with water (×2)
  4. dry with materialbrine, and dried (MgSO4)
  5. customThe solvent was removed by evaporation
  6. customthe residue was recrystallised from ethyl acetate/hexane

Sources & evidence

ORD record
ord-09b79a7ea1474a55a3eedd86affb6d9a
Source dataset
uspto-grants-2005_05
Patent number
US06897210B2

Reaction notes

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