Sodium Hydroxide → HCID 22479213, compound

HRID 2182596Notes

Reaction equation

HRID 2182596 reaction equation
[OH-].[Na+].C[O:4][C:5]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:40]=[CH:39][C:18]([CH2:19][C:20]23[C:28](=[O:29])[N:27]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[C:32]([Cl:37])[CH:31]=4)[C:26](=[O:38])[N:25]2[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:17][CH:16]=1)=[O:6]>CO.O>[C:5]([CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:16]=[CH:17][C:18]([CH2:19][C:20]23[C:28](=[O:29])[N:27]([C:30]4[CH:31]=[C:32]([Cl:37])[CH:33]=[C:34]([Cl:36])[CH:35]=4)[C:26](=[O:38])[N:25]2[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:39][CH:40]=1)([OH:6])=[O:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22479244HCID 22479244, compound

Product 1

HCID 22479213HCID 22479213, compoundYield 101.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

An aqueous solution of NaOH (2 mL; 0.5 N) was added to a solution of 6-[4-[2-(2-methoxycarbonylethyl)phenyl]benzyl]-8-(3,5-dichlorophenyl)-1,8-diazabicyclo[4.3.0]nonane-7,9-dione (0.11 g) in MeOH (7 mL) and the mixture was stirred for 18 hours. The reaction mixture was acidified, diluted with water and extracted with EtOAc. The extract was washed with water, brine, dried (MgSO4), filtered, and concentrated to give the titled compound (0.109 g). MS (m/z) 559 (M++Na).

Workup

  1. extractionextracted with EtOAc
  2. washThe extract was washed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2a94b0b5db78490f95062afc3a965b30
Source dataset
uspto-grants-2005_05
Patent number
US06897225B1

Reaction notes

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