HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-Chloro-1,3-difluoro-7-oxabicyclo[4.1.0]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,6-Dichloro-2,6-difluorocyclohexanol | HCID 18970954 | — |
| Reactant | 1,3-Dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970966 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chloro-1,3-difluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970945 | — |
Reaction Steps
The same procedure was employed as for the preparation of 2e in Example 17: it was performed with 0.18 g (0.88 mmol) of pure alcohol 1g, 3 cm of distilled water and 0.12 g (3 mmol) of sodium hydroxide, reaction time was 1 h 15 min; ether extraction (3×12 cm). After treatment, 0.13 g of epoxide 2f were obtained (macrobore GC purity>98%). The yield of epoxide 2f was 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424460 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-786d484b8dd64db3b16c5df468086393 |
| Source note | uspto-grants-1995_06 |