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HRID2182641

反应详情

EQUATION

反应方程式

HRID 2182641 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(F)cc1C(C)(C)CC(O)(CNc1nccc2ccccc12)C(F)(F)F
HCID21948812

未命名化合物

结构：BrB(Br)Br.ClCCl
HCID22277759

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(CC(O)(CNc1nccc2ccccc12)C(F)(F)F)c1cc(F)ccc1O
HCID21948922

未命名化合物

收率 52.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCCC.CCOC(C)=O
溶剂HCID21226206

未命名化合物

PROCEDURE

实验过程

Analogously to Example 2, 65 mg (0.15 mmol) of 4-(5-fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol is reacted with 2.7 ml of 1 M boron tribromide-CH2Cl2 solution. After chromatography on silica gel with hexane-ethyl acetate (0-80%), 33 mg of the product is obtained.