HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol → 4-(5-Fluoro-2-hydroxyphenyl)-1-(isoquinoline-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol | HCID 21948812 | — |
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 4-(5-Fluoro-2-hydroxyphenyl)-1-(isoquinoline-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol | HCID 21948922 | 52.1% |
Reaction Steps
Analogously to Example 2, 65 mg (0.15 mmol) of 4-(5-fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol is reacted with 2.7 ml of 1 M boron tribromide-CH2Cl2 solution. After chromatography on silica gel with hexane-ethyl acetate (0-80%), 33 mg of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897224B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-0c7f35fd182d4a31ac8cde07c19e5a7f |
| Source note | uspto-grants-2005_05 |