HCID 21948814, compound → HCID 21948846, compound

HRID 2182670Notes

Reaction equation

HRID 2182670 reaction equation
[C:1]([C:4]1[C:13]([NH:14][CH3:15])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:16]([O-])=O)[N:5]=1)(=[O:3])[CH3:2].[H][H]>C(OCC)(=O)C.[Pd]>[C:1]([C:4]1[C:13]([NH:14][CH3:15])=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH2:16])[N:5]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 21948814HCID 21948814, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21948846HCID 21948846, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

650 mg (2.7 mmol) of 2-acetyl(methyl)amino-5-nitroquinoline and 161 mg of 10% Pd—C are stirred in 25 ml of ethyl acetate for 2 hours in a hydrogen atmosphere at room temperature. The batch is filtered and concentrated by evaporation: 490 mg of product.

Workup

  1. filtrationThe batch is filtered
  2. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-7d2eed752ae04030a8820d23b9d55b48
Source dataset
uspto-grants-2005_05
Patent number
US06897224B2

Reaction notes

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