反应详情

温度

150 °C

43 (2.5 g, 10.5 mmol) was added to a solution of acetic acid (62.5 mL) and hydrobromic acid 48% (70 mL) and the reaction mixture was heated at 150° C. for 4 h. The reaction mixture was then cooled to rt and evaporated to dryness. The residue was diluted in hot CH2Cl2 (40 mL) and filtered. The filtrate was evaporated to dryness to give 44 (1.74 g, 91%) which was used as such in the next step:

1. temperatureThe reaction mixture was then cooled to rt
2. customevaporated to dryness
3. additionThe residue was diluted in hot CH2Cl2 (40 mL)
4. filtrationfiltered
5. customThe filtrate was evaporated to dryness