反应详情

温度

65 °C

To the solution of the 3-[2-[4-(3-methoxy-propoxy)-3-methyl-pyridin-2-yl-methanesulfinyl]-benzimidazole-1-sulfonyl]benzoic acid 2-(toluene-4-sulfonyl)ethyl ester (Intermediate 48, 1.5 g, 2.0 mmol) in 15 mL of CH3CN was added a solution of NaHCO3 (200 mg, 2.4 mmol, 1.2 eq) in 7 mL of H2O at room temperature, and then the mixture was heated to 65° C. for 2.5 h. Thereafter most of CH3CN was removed, the mixture was extracted with EtOAc, and the aqueous layer was lyophilized overnight. The solid was dissolved in CH2Cl2, and then the mixture was filtered to remove insoluble solids. The filtrate was concentrated to near dryness. The residual oil was dissolved in about 2 mL of CH2Cl2 and EtOAc-ether (1:1) was added to precipitate a white solid. The precipitate was collected by filtration, washed with EtOAc-ether (1:1), and dried under vacuum to give 700 mg (60%) of 3-[2-[4-(3-methoxy-propoxy)-3-methyl-pyridin-2-yl-methanesulfinyl]-benzimidazole-1-sulfonyl]benzoic acid sodium salt (Compound 24) as a white solid.

1. customThereafter most of CH3CN was removed
2. extractionthe mixture was extracted with EtOAc
3. dissolutionThe solid was dissolved in CH2Cl2
4. filtrationthe mixture was filtered
5. customto remove insoluble solids
6. concentrationThe filtrate was concentrated
7. dissolutionThe residual oil was dissolved in about 2 mL of CH2Cl2
8. additionEtOAc-ether (1:1) was added
9. customto precipitate a white solid
10. filtrationThe precipitate was collected by filtration
11. washwashed with EtOAc-ether (1:1)
12. customdried under vacuum