Sodium Bicarbonate → HCID 178493628, compound

HRID 2182904Notes

Reaction equation

HRID 2182904 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:25]([C:28]2[CH:38]=[CH:37][C:31]([O:32][CH2:33][C:34]([OH:36])=[O:35])=[CH:30][CH:29]=2)(=[O:27])=[O:26])[C:6]2[NH:10][C:9]([S:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:8][C:7]=2[CH:24]=1.C(=O)(O)[O-:40].[Na+:43]>C(COC)OC.O>[Na+:43].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:25]([C:28]2[CH:38]=[CH:37][C:31]([O:32][CH2:33][C:34]([O-:36])=[O:35])=[CH:30][CH:29]=2)(=[O:26])=[O:27])[C:6]2[NH:10][C:9]([S:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)(=[O:40])=[O:12])=[N:8][C:7]=2[CH:24]=1

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 178493626HCID 178493626, compound

Product 1

HCID 178493628HCID 178493628, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

To a suspension of the sulfoxide acid (4.47 g, 0.008 mol) in glyme (75 mL) was added a solution of sodium bicarbonate (0.672 g, 0.008 mol) in water (50 mL). The reaction mixture was extracted with ethyl acetate (4×50 mL). The combined organic layers were back extracted with water (2×25 mL). The combined aqueous layers were lyophilized to give 4.1 g (88%) of the title compound.

Workup

  1. extractionThe reaction mixture was extracted with ethyl acetate (4×50 mL)
  2. extractionThe combined organic layers were back extracted with water (2×25 mL)

Sources & evidence

ORD record
ord-f8022c0bcd7c4dd98209431701b4f5de
Source dataset
uspto-grants-2005_05
Patent number
US06897227B2

Reaction notes

Loading…