HCID 9903722, compound → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

HRID 2183422Notes

Reaction equation

HRID 2183422 reaction equation
[OH:1][CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[NH2:4].[CH3:13][N:14]([CH2:16][CH:17]1[C:22]([OH:31])([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:15].[S:32]([OH:36])([OH:35])(=[O:34])=[O:33].OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1N.CN(CC1C(O)(C2C=C(OC)C=CC=2)CCCC1)C.Cl>O>[S:32]([OH:36])([OH:35])(=[O:34])=[O:33].[OH:1][CH:2]1[O:10][C@H:9]([CH2:11][OH:12])[C@@H:7]([OH:8])[C@H:5]([OH:6])[C@H:3]1[NH2:4].[CH3:15][N:14]([CH2:16][CH:17]1[C:22]([OH:31])([C:23]2[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:13]

Participants

6

Reactant 3

HCID 9903722HCID 9903722, compoundHCID 9971980Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride (1:1)HCID 86585181HCID 86585181, compound

Product 2

HCID 55232-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanolHCID 9903722HCID 9903722, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Solutions of glucosamine/tramadol combinations with different ratios were prepared and concentrations of each component expressed as mg per 10 mL of distilled water. For example, 250 mg of glucosamine sulfate and 10 mg of tramadol HCL were added to 10 mL of water with 2 drops of TWEEN®-80, a pharmacological dispersant, to yield a glucosamine sulfate to tramadol weight ratio of 25:1 (250 mg: 10 mg), which corresponds to a glucosamine to tramadol weight ratio of about 15:1.

Sources & evidence

ORD record
ord-8f5d254a42b94f4c9b90749ad2a35e37
Source dataset
uspto-grants-2005_05
Patent number
US06900189B2

Reaction notes

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