反应详情

4.68 g aluminium chloride (35.15 mmol) are dissolved in 45 ml dichloromethane and treated dropwise with 3.38 g (16.74 mmol) bromoacetyl bromide at 0° C. After 30 min 3 g (16.74 mmol) 4-cyanobiphenyl, dissolved in 15 ml dichloromethane, are added dropwise. The reaction mixture is stirred overnight at ambient temperature, added to ice-water and extracted 2 times with dichloromethane. The organic phase is washed with water and brine, dried and evaporated. The residue is triturated with petrol ether, filtered and dried. Yield: 4.24 g (83%).

1. additionare added dropwise
2. extractionextracted 2 times with dichloromethane
3. washThe organic phase is washed with water and brine
4. customdried
5. customevaporated
6. customThe residue is triturated with petrol ether
7. filtrationfiltered
8. customdried