HCID 22135134, compound → tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate

HRID 2183444Notes

Reaction equation

HRID 2183444 reaction equation
[CH3:1][N:2]([CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1)C(OCC1C=CC=CC=1)=O>CCOC(C)=O.CCO>[CH3:1][NH:2][CH2:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:18][CH2:19]1

Participants

4

Reactant 1

HCID 22135134HCID 22135134, compound

Product 1

HCID 21934652tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylateYield 106.1%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Using Deprotection Method A, 4-[(N-methyl)benzyloxycarbonylaminomethyl]-1-Boc-piperidine (0.30 g, 0.83 mmol) in EtOAc (5 mL) and EtOH (14 mL) afforded 201 mg (88%) of the title compound which was used without further purification.

Sources & evidence

ORD record
ord-a81eaebf9193431a8fe45175d70c01fe
Source dataset
uspto-grants-2005_05
Patent number
US06900196B2

Reaction notes

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