HCID 22257623, compound → HCID 22257597, compound

HRID 2183448Notes

Reaction equation

HRID 2183448 reaction equation
[C:1]([CH:8]([NH2:15])[C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>[Rh]>[C:1]([CH:8]([NH2:15])[CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

3

Reactant 1

HCID 22257623HCID 22257623, compound

Product 1

HCID 22257597HCID 22257597, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 23948RhodiumCatalyst

Procedure

A solution of 4-(Boc-aminomethyl)pyridine (20 g, 96 mmol) was treated with 5 g of 5% rhodium on carbon and was stirred under 4.1 bar (60 psig) of H2 overnight. Filtration through diatomaceous earth and evaporation of the solvent afforded 20 g (99%) of the title compound.

Workup

  1. filtrationFiltration
  2. customthrough diatomaceous earth and evaporation of the solvent

Sources & evidence

ORD record
ord-2afa3b6d1f25405dac4244226f9ec311
Source dataset
uspto-grants-2005_05
Patent number
US06900196B2

Reaction notes

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