3-(2-Fluorophenyl)prop-2-enoic acid → (S)-3-(2-fluoro-phenyl)-N-{1-[3-(pyrimidin-2-yloxy)-phenyl]-ethyl}-acrylamide

HRID 2183470Notes

Reaction equation

HRID 2183470 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=O.[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[O:19][C:20]1[CH:21]=[C:22]([C@@H:26]([NH2:28])[CH3:27])[CH:23]=[CH:24][CH:25]=1>>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([NH:28][C@H:26]([C:22]1[CH:23]=[CH:24][CH:25]=[C:20]([O:19][C:14]2[N:13]=[CH:18][CH:17]=[CH:16][N:15]=2)[CH:21]=1)[CH3:27])=[O:8]

Participants

3

Reactant 2

HCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 60004105HCID 60004105, compound

Product 1

HCID 69801962(S)-3-(2-fluoro-phenyl)-N-{1-[3-(pyrimidin-2-yloxy)-phenyl]-ethyl}-acrylamide

Procedure

The title compound was prepared from 2-fluorocinnamic acid following the general procedures as described for Example 1 with the exception that (S)-1-[3-(pyrimidin-2-yloxy)-phenyl]-ethylamine was used.

Sources & evidence

ORD record
ord-63e168beb2784e2aaf7a84d6829b912d
Source dataset
uspto-grants-2005_05
Patent number
US06900210B2

Reaction notes

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