HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2183482Generated: November 2, 2026
Methanol → 4-Chloro-3-cyano-5-methoxymethyl-pyrrolo[1,2-b]pyridazine-6-carboxylic Acid Ethyl Ester
https://huagongshe.com/reaction/2183482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Bromomethyl-4-chloro-3-cyano-pyrrolo[1,2-b]pyridazine-6-carboxylic Acid Ethyl Ester | HCID 20791631 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-3-cyano-5-methoxymethyl-pyrrolo[1,2-b]pyridazine-6-carboxylic Acid Ethyl Ester | HCID 20791628 | 98.4% |
Reaction Steps
To a solution of compound 16A (31 mg, 0.09 mmol) in 1:1 MeOH:CH2Cl2 (2 mL) was added NaHCO3 (30 mg, 0.36 mmol). The reaction was kept at room temperature for 3 h, heated to 70° C. for 1 h, cooled to room temperature, concentrated to dryness, redissolved in CH2Cl2 and filtered. The filtrate was concentrated to give compound 17A as a yellow solid (26 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06900208B2 |
|---|
| Source dataset | uspto-grants-2005_05 |
|---|
| ORD ID | ord-879141e1d5bb483f970ee6f13b75835a |
|---|
| Source note | uspto-grants-2005_05 |
|---|
