反应详情

A mixture of 2-bromo-1-(4-chlorobenzo[b]thiophen-2-yl]ethan-1-one (0.42 g), 2-imidazolidinethione (0.11 g) and ethanol (9 ml) was heated under reflux for 20 minutes. Acetic acid (4 ml) was added and the mixture was heated under reflux for 17 hours then cooled in ice-water. The resulting solid was collected by filtration and dried in vacuo at 60° C. to give 3-(4-chlorobenzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.37 g) as a white solid, m.p. 273-274° C.

1. temperaturewas heated
2. temperatureunder reflux for 20 minutes
3. temperaturethe mixture was heated
4. temperatureunder reflux for 17 hours
5. filtrationThe resulting solid was collected by filtration
6. customdried in vacuo at 60° C.