Ethanol → HCID 22473835, compound

HRID 2183649Notes

Reaction equation

HRID 2183649 reaction equation
[Br:1][CH:2]([CH3:15])[C:3]([C:5]1[S:9][C:8]2[C:10]([Cl:14])=[CH:11][CH:12]=[CH:13][C:7]=2[CH:6]=1)=O.[NH:16]1[CH2:20][CH2:19][NH:18][C:17]1=[S:21].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:10]1[C:8]2[S:9][C:5]([C:3]3[N:18]4[CH2:19][CH2:20][N:16]=[C:17]4[S:21][C:2]=3[CH3:15])=[CH:6][C:7]=2[CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 22473722HCID 22473722, compound

Product 1

HCID 22473835HCID 22473835, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2-bromo-1-(7-chlorobenzo[b]thiophen-2-yl)propan-1-one (2.32 g), 2-imidazolidinethione (0.53 g), ethanol (25 ml) and acetic acid (12.5 ml) was heated under reflux for 3 hours and allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol and dried in vacuo to give 3-(7-chlorobenzo[b]thiophen-2-yl)-2-methyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (1.12 g) as a white solid, m.p. 294-295° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

Sources & evidence

ORD record
ord-48316ed798a141bab93ef3a924095c5a
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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