Sodium Bicarbonate → HCID 22473634, compound

Participants

Reaction Steps

Saturated aqueous sodium hydrogencarbonate solution (100 ml) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.38 g) in dichloromethane (50 ml), and the mixture was stirred at ambient temperature for 2 hours. The organic phase was separated, washed with water (50 ml) and saturated aqueous sodium chloride solution (50 ml), dried (Na2SO4), and the solvent was removed in vacuo to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.45 g) as a yellow solid which was used without further purification.

Provenance & Evidence