Sodium Bicarbonate → HCID 22473634, compound

HRID 2183652Notes

Reaction equation

HRID 2183652 reaction equation
C(=O)([O-])O.[Na+].Br.[S:7]1[CH:11]=[CH:10][C:9]2[C:12]([C:16]3[N:17]4[CH2:23][CH2:22][N:21]=[C:18]4[S:19][CH:20]=3)=[CH:13][CH:14]=[CH:15][C:8]1=2>ClCCl>[S:7]1[CH:11]=[CH:10][C:9]2[C:12]([C:16]3[N:17]4[CH2:23][CH2:22][N:21]=[C:18]4[S:19][CH:20]=3)=[CH:13][CH:14]=[CH:15][C:8]1=2

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22473633HCID 22473633, compound

Product 1

HCID 22473634HCID 22473634, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Saturated aqueous sodium hydrogencarbonate solution (100 ml) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.38 g) in dichloromethane (50 ml), and the mixture was stirred at ambient temperature for 2 hours. The organic phase was separated, washed with water (50 ml) and saturated aqueous sodium chloride solution (50 ml), dried (Na2SO4), and the solvent was removed in vacuo to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.45 g) as a yellow solid which was used without further purification.

Workup

  1. customThe organic phase was separated
  2. washwashed with water (50 ml) and saturated aqueous sodium chloride solution (50 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-830c14f546694cde8fd012f561d2d651
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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