Sodium Bicarbonate → HCID 22473608, compound

HRID 2183667Notes

Reaction equation

HRID 2183667 reaction equation
C(=O)([O-])O.[Na+].Br.[S:7]1[CH:11]=[CH:10][C:9]2[CH:12]=[C:13]([C:16]3[N:17]4[CH2:23][CH2:22][N:21]=[C:18]4[S:19][CH:20]=3)[CH:14]=[CH:15][C:8]1=2>ClCCl>[S:7]1[CH:11]=[CH:10][C:9]2[CH:12]=[C:13]([C:16]3[N:17]4[CH2:23][CH2:22][N:21]=[C:18]4[S:19][CH:20]=3)[CH:14]=[CH:15][C:8]1=2

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22473652HCID 22473652, compound

Product 1

HCID 22473608HCID 22473608, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Saturated aqueous sodium hydrogencarbonate solution (100 ml) was added over 10 minutes to a stirred suspension of 3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.6 g) in dichloromethane (100 ml), the mixture was stirred at ambient temperature for 45 minutes, then the organic layer was separated, washed with water (2×75 ml) and saturated aqueous sodium chloride solution (75 ml), dried (MgSO4) and the solvent was removed in vacuo to give 3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.9 g) as an orange solid which was used without further purification.

Workup

  1. customthe organic layer was separated
  2. washwashed with water (2×75 ml) and saturated aqueous sodium chloride solution (75 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-5a2f39fbff5f4722986b60704b75712a
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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