3-bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 3-Fluoro-5-(7-trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 3′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-fluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as a yellow solid: δH (360 MHz, DMSO) 7.55 (1H, d, J 7), 7.62-7.69 (2H, m), 7.80-7.87 (4H, m), 8.03 (1H, d, J 8), 8.40 (1H, s), 9.47 (1H, d, J 7); m/z (ES+) 383 (M++H).

Provenance & Evidence