3-Bromopyridine → 3-(2-Fluorophenyl)pyridine

HRID 2183940Notes

Reaction equation

HRID 2183940 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1B(O)O>>[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 27343542-Fluorophenylboronic acid

Product 1

HCID 132706453-(2-Fluorophenyl)pyridine

Procedure

3-Bromopyridine and 2-fluorobenzeneboronic acid were coupled using the procedure described in Example 31 to afford 3-(2-fluorophenyl)pyridine as a pale yellow oil which crystallised on standing: δH (360 MHz, DMSO) 7.33-7.40 (2H, m), 7.46-7.55 (2H, m), 7.61 (1H, ddd, J 8, 8 and 2), 7.96-8.01 (1H, m), 8.61 (1H, dd, J 5 and 2), 8.77 (1H, s).

Sources & evidence

ORD record
ord-ef4c73b7fe9544c591186922daf8fa41
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

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