Bis(2-amino-1H-imidazole) sulphate → HCID 69708146, compound

HRID 2183997Notes

Reaction equation

HRID 2183997 reaction equation
CC1(C)OC(C(=O)C)(C)CO1.C(O[CH:15](OCC)[CH2:16][C:17]([C:19]1([CH3:26])[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]1)=O)C.S(O)(O)(=O)=O.[NH2:35][C:36]1[NH:37][CH:38]=[CH:39][N:40]=1>>[CH3:25][C:21]1([CH3:24])[O:20][C:19]([C:17]2[CH:16]=[CH:15][N:37]3[CH:38]=[CH:39][N:40]=[C:36]3[N:35]=2)([CH3:26])[CH2:23][O:22]1

Participants

4

Reactant 3

HCID 135136Bis(2-amino-1H-imidazole) sulphateHCID 12231420HCID 12231420, compoundHCID 22473551HCID 22473551, compound

Product 1

HCID 69708146HCID 69708146, compoundYield 96%

Procedure

1-(2,2,4-Trimethyl-[1,3]dioxolan-4-yl)ethanone was converted to 3,3-diethoxy-1-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)propan-1-one as described in Example 3 then condensed with 2-aminoimidazole sulfate as in Example 2 to give 7-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)imidazo[1,2-α]pyrimidine as a pale orange solid (7.10 g, 96%): δH (360 MHz, d6-DMSO) 1.31 (3H, s), 1.47 (3H, s), 1.57 (3H, s), 4.05 (1H, d, J 9), 4.49 (1H, d, J 9), 7.27 (1H, d, J 7), 7.71 (1H, d, J 1), 7.92 (1H, d, J 1), 8.98 (1H, d, J 7).

Sources & evidence

ORD record
ord-c26dbdf90b424e0fbff52b8b1581da82
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

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