HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Methyl-phenyl-amino)-acetic acid ethyl ester → 2-(N-Methylanilino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
| Reactant | Ethyl N-methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-glycinate | HCID 10406140 | — |
| Product | 2-(N-Methylanilino)ethanol | HCID 62340 | 89% |
Reaction Steps
Prepared in the manner of Example 23 except ethyl N-methyl-N-phenylglycinate was substituted for ethyl N-methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}glycinate. Purification by flash chromatography (1:1 hexanes/EtOAc) afforded the title compound as a yellow oil (89%). MS (ES+) m/z 152 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900244B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-e453453291b8478f9fd1e7247cb8cf96 |
| Source note | uspto-grants-2005_05 |