HRID218425

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C(=O)[O-])[C@H](CN=[N+]=[N-])C[C@H]1CCCOC1

HCID86637153

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)OC(C)(C)C)[C@H](CN)C[C@H]1CCCOC1

HCID58011482

tert-Butyl {(2S)-1-amino-3-[(3R)-oxan-3-yl]propan-2-yl}methylcarbamate

C14H28N2O3

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Hydrogenation of (S)-1-azido-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-yl(methyl)carbamate (62 mg, 0.51 mmol) was carried out in EtOAc (20 mL), 10% Pd/C (15 mg) under 40 psi of H2 for 2 h. After filtration 52 mg of tert-butyl (S)-1-amino-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate was obtained, yield 91%. MS ESI+ve m/z 273 (M+H).

WORKUP

后处理

filtrationAfter filtration 52 mg of tert-butyl (S)-1-amino-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate
customwas obtained