Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)- → Bms-488043

HRID 2184255Notes

Reaction equation

HRID 2184255 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12](C(=O)C(C2C3C(=NC=CC=3)NC=2)=O)[C@H:11](C)[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][O:30][C:31]1[CH:39]=[N:38][C:37]([O:40][CH3:41])=[C:36]2[C:32]=1[C:33]([C:42](=[O:46])[C:43]([O-:45])=O)=[CH:34][NH:35]2.[K+]>>[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:43](=[O:45])[C:42]([C:33]2[C:32]3[C:36](=[C:37]([O:40][CH3:41])[N:38]=[CH:39][C:31]=3[O:30][CH3:29])[NH:35][CH:34]=2)=[O:46])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5495793Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)-HCID 22893810Potassium (4,7-dimethoxy-6-azaindol-3-yl)-oxoacetate

Product 1

HCID 507806Bms-488043

Procedure

Compound 5ao, N-(benzoyl)-N′-[(4,7-dimethoxy-6-azaindol-3-yl)-oxoacetyl]-piperazine was prepared by the same method used to prepare compound 5a but the starting material was Potassium (4,7-dimethoxy-6-azaindole-3-yl)-oxoacetate. The compound was purified by silica gel chromatography using EtOAc as the eluting solvent to give a white solid.

Workup

  1. customThe compound was purified by silica gel chromatography
  2. customto give a white solid

Sources & evidence

ORD record
ord-67815cdc8a7744d480ba3c925fc1920d
Source dataset
uspto-grants-2005_05
Patent number
US06900323B2

Reaction notes

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