Hydrochloric Acid → HCID 178524904, compound

HRID 2184276Notes

Reaction equation

HRID 2184276 reaction equation
[C:1]1([CH:7]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]#N)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:27].[Na+].Cl.[OH2:30]>>[C:1]1([CH:7]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]([OH:30])=[O:27])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 178419062HCID 178419062, compound

Product 1

HCID 178524904HCID 178524904, compound

Procedure

To a suspension of 6-[(2,2-diphenylethyl)amino]-9H-purine-2-carbonitrile (12.5 g, 0.0368 moles) (Preparation 15) in a mixture of industrial methylated spirits (80 ml) and deionised water (35 ml) was added sodium hydroxide (1.2 g, 0.13 moles) and the resultant mixture was heated under reflux for 17 hours during which time a clear solution was formed. The mixture was cooled to ambient temperature and was acidified by the addition of 1 M aqueous hydrochloric acid solution (105 ml) to give a suspension. The solid was collected by filtration and was dried under reduced pressure at 50° C. to give the title compound as a colourless solid (13.5 g), m.p. 241-249° C.

Workup

  1. temperatureunder reflux for 17 hours during which time a clear solution
  2. customwas formed
  3. customto give a suspension
  4. filtrationThe solid was collected by filtration
  5. customwas dried under reduced pressure at 50° C.

Sources & evidence

ORD record
ord-994a2952caa7486092332d6b41b5eaa2
Source dataset
uspto-grants-2005_05
Patent number
US06900309B1

Reaction notes

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