4-Fluorobenzyl bromide → 3-[4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enoic Acid

HRID 2184366Notes

Reaction equation

HRID 2184366 reaction equation
[CH:1]1[C:6](/[CH:7]=[CH:8]/[C:9]([OH:11])=[O:10])=[CH:5][CH:4]=[C:3]([OH:12])[CH:2]=1.[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:12][C:3]2[CH:4]=[CH:5][C:6]([CH:7]=[CH:8][C:9]([OH:11])=[O:10])=[CH:1][CH:2]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 637542P-Coumaric Acid

Product 1

HCID 8053823-[4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enoic AcidYield 56%

Procedure

The title compound is prepared in analogy to example 12 a) from p-cumaric acid and 4-fluorobenzyl bromide. Yield=56%. Colorless solid. MS: m/e=271.0 (M−H).

Sources & evidence

ORD record
ord-8f962224259842e4bd48ca21674d1624
Source dataset
uspto-grants-2005_05
Patent number
US06900354B2

Reaction notes

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