Benzonitrile, 3-(bromomethyl)- → 3-{4-[(3-Cyanophenyl)methoxy]phenyl}-N-methylprop-2-enamide

HRID 2184368Notes

Reaction equation

HRID 2184368 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.Br[CH2:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[C:19]#[N:20]>>[C:19]([C:18]1[CH:17]=[C:16]([CH:23]=[CH:22][CH:21]=1)[CH2:15][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[CH:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:6][CH:7]=1)#[N:20]

Participants

3

Reactant 2

HCID 97249Benzonitrile, 3-(bromomethyl)-HCID 544005703-(4-Hydroxyphenyl)-N-methylprop-2-enamide

Product 1

HCID 692917153-{4-[(3-Cyanophenyl)methoxy]phenyl}-N-methylprop-2-enamideYield 75%

Procedure

The title compound is prepared in analogy to example 11 b) from 3-(4-hydroxy-phenyl)-N-methyl-acrylamide and 3-bromomethyl-benzonitrile. Yield=75%. Colorless solid. MS: m/e=293.2 (M++H).

Sources & evidence

ORD record
ord-130f55bbee4e4e5b800fdf98d91a15bc
Source dataset
uspto-grants-2005_05
Patent number
US06900354B2

Reaction notes

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