p-Xylyl bromide → N-Methyl-3-{4-[(4-methylphenyl)methoxy]phenyl}prop-2-enamide

HRID 2184369Notes

Reaction equation

HRID 2184369 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([NH:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.Br[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1>>[CH3:13][NH:12][C:10](=[O:11])[CH:9]=[CH:8][C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 7721p-Xylyl bromideHCID 544005703-(4-Hydroxyphenyl)-N-methylprop-2-enamide

Product 1

HCID 68668893N-Methyl-3-{4-[(4-methylphenyl)methoxy]phenyl}prop-2-enamideYield 44%

Procedure

The title compound is prepared in analogy to example 11 b) from 3-(4-hydroxy-phenyl)-N-methyl-acrylamide and 1-bromomethyl-4-methyl-benzene. Yield=44%.

Sources & evidence

ORD record
ord-cc31eda76e1444879e035fa48e2ca55c
Source dataset
uspto-grants-2005_05
Patent number
US06900354B2

Reaction notes

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