HCID 22476587, compound → HCID 22476602, compound

HRID 2184409Notes

Reaction equation

HRID 2184409 reaction equation
[CH3:1][CH:2]([S:4]([NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[O:14]CC1C=CC=CC=1)(=[O:6])=[O:5])[CH3:3]>[Pd].C(O)C>[OH:14][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:8]1[NH:7][S:4]([CH:2]([CH3:3])[CH3:1])(=[O:6])=[O:5]

Participants

4

Reactant 1

HCID 22476587HCID 22476587, compound

Product 1

HCID 22476602HCID 22476602, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

[(Methylethyl)sulfonyl][2-(phenylmethoxy)cyclohexyl]amine (11.41 g, 36.6 mmol) and 10% palladium on carbon (1.40 g) were combined in ethanol (300 mL) and placed on the power shaker under a hydrogen atmosphere at 60 psi's overnight. The solution was then filtered over a Celite® mat and the resulting filtrate was concentrated under reduced vacuum to yield the intermediate title compound (6.78 g, 84%) as a white solid. Ion Spray M.S. 222.1 (M*+1). Calculated for C9H19NO3S: Theory: C 48.84, H 8.65, N 6.32. Found: C 49.10, H 8.84, N 6.42.

Workup

  1. customs overnight
  2. filtrationThe solution was then filtered over a Celite® mat
  3. concentrationthe resulting filtrate was concentrated under reduced vacuum

Sources & evidence

ORD record
ord-85133dfe218442858bca92181d64c85a
Source dataset
uspto-grants-2005_05
Patent number
US06900353B2

Reaction notes

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