Hydrochloric Acid → 3-Methyl-4-[2-(trifluoromethyl)phenyl]benzoic acid

Participants

Reaction Steps

To a solution of 2-methyl-2′-trifluoromethyl-[1,1′-biphenyl]-4-carboxylic acid methyl ester of Step B (1.9 g, 6.5 mmol) in tetrahydrofuran (30 mL) was added 1 N sodium hydroxide (13 mL, 13 mmol). The reaction mixture was heated at reflux overnight, then cooled and acidified with 2 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate and the combined extracts were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give 1.65 g of the title compound as a white solid, m.p. 171-174° C.

Provenance & Evidence