反应详情

To a solution of 2-methyl-2′-trifluoromethyl-[1,1′-biphenyl]-4-carboxylic acid methyl ester of Step B (1.9 g, 6.5 mmol) in tetrahydrofuran (30 mL) was added 1 N sodium hydroxide (13 mL, 13 mmol). The reaction mixture was heated at reflux overnight, then cooled and acidified with 2 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate and the combined extracts were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give 1.65 g of the title compound as a white solid, m.p. 171-174° C.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux overnight
3. temperaturecooled
4. extractionThe aqueous layer was extracted with ethyl acetate
5. dry with materialthe combined extracts were dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo