Diethanolamine → HCID 10230793, compound

HRID 2184460Notes

Reaction equation

[C:1]1([C:11]2[CH:35]=[CH:34][C:14]([C:15]([N:17]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[CH2:21][N:20]4[C:28]([C:31](O)=[O:32])=[CH:29][CH:30]=[C:19]4[CH2:18]3)=[O:16])=[CH:13][CH:12]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH:36]([CH2:40][CH2:41][OH:42])[CH2:37][CH2:38][OH:39]>>[OH:39][CH2:38][CH2:37][N:36]([CH2:40][CH2:41][OH:42])[C:31]([C:28]1[N:20]2[C:19]([CH2:18][N:17]([C:15](=[O:16])[C:14]3[CH:34]=[CH:35][C:11]([C:1]4[C:10]5[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=5)[CH:4]=[CH:3][CH:2]=4)=[CH:12][CH:13]=3)[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21]2)=[CH:30][CH:29]=1)=[O:32]

Participants

Reactant 2

HCID 8113Diethanolamine

HCID 21947718HCID 21947718, compound

Product 1

HCID 10230793HCID 10230793, compound

Procedure

The title compound was prepared by coupling the 10-[4-(naphthalen-1-yl)benzoyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of Step D, with diethanolamine (1.25 equiv) in the manner of Example 1, Step G.

Sources & evidence

ORD record: ord-5160740d47b4426ebfecf77b955a8466
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06900200B2

Reaction notes

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