Sodium Hydroxide → HCID 22457561, compound

HRID 2184718Notes

Reaction equation

HRID 2184718 reaction equation
S(O)(O)(=O)=O.[CH3:6][S:7][C:8](=[NH:10])[NH2:9].[OH-:11].[Na+].[CH2:13]([O:16][C:17](Cl)=[O:18])[CH:14]=[CH2:15]>C(=O)(O)[O-].[Na+].C(Cl)Cl>[CH2:13]([O:16][C:17]([N:10]([C:17]([O:16][CH2:13][CH:14]=[CH2:15])=[O:11])[C:8](=[NH:9])[S:7][CH3:6])=[O:18])[CH:14]=[CH2:15]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 18052Allyl chloroformateHCID 752702-Methyl-2-thiopseudourea sulfate

Product 1

HCID 22457561HCID 22457561, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 516892Sodium BicarbonateSolvent

Procedure

2-methyl-2-thiopseudourea sulfate (2 g) was dissolved in sodium bicarbonate (10% soln., 20 ml. To this was added methylene chloride (20 ml) followed by sodium hydroxide solution (5N, 2.8 ml) and allylchloroformate (4.5 ml) added dropwise over 5 min. The reaction was allowed to stir at room temperature for 3 hr., diluted with methylene chloride and the organic phase was separated. The aqueous phase was extracted once with methylene chloride and the combined organic phase was washed with water, satd. NaCl, and dried over MgSO4 and evaporated to give the product (3.7 g)

Workup

  1. additionadded dropwise over 5 min
  2. customthe organic phase was separated
  3. extractionThe aqueous phase was extracted once with methylene chloride
  4. washthe combined organic phase was washed with water
  5. dry with materialNaCl, and dried over MgSO4
  6. customevaporated

Sources & evidence

ORD record
ord-a3b85f27b8154982b280f15ac7e7af72
Source dataset
uspto-grants-2002_06
Patent number
US06399597B1

Reaction notes

Loading…