反应详情

温度

0 °C

To a solution of 1H-pyrazolo[3,4-c]pyridine-5-carboxylic acid, methyl ester (1.5 g, 8.5 mmol) in THF (350 mL) at 0° C. was added LAH (958 mg) in two portions. The reaction was stirred at 0° C. for 1.5 hr, and at rt for 1 hr. The reaction was quenched with con. NaOH at 0° C., and the solid was filtered off and washed with MeOH. The filtrate was concentrated. Purification by column afforded 1H-pyrazolo[3,4-c]pyridine-5-methanol (1.23 g, 96%).

1. waitat rt for 1 hr
2. customThe reaction was quenched with con
3. filtrationNaOH at 0° C., and the solid was filtered off
4. washwashed with MeOH
5. concentrationThe filtrate was concentrated
6. customPurification by column