反应详情

A solution of methyl 4-oxo-3-(piperidylmethyl)-4-(3-pyridyl)butanoate (4 g) in ethanol (10 mL) and 4N HCl/dioxane (4.0 mL) was heated at 80° C. for 12 hrs. The reaction mixture was concentrated and purified on flash chromatography (SIO2, CHCl3: MeOH: CH3COOH=10: 1:0.5) to give 2.28 g of the title compound.

1. concentrationThe reaction mixture was concentrated
2. custompurified on flash chromatography (SIO2, CHCl3: MeOH: CH3COOH=10: 1:0.5)