HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-oxo-3-(piperidylmethyl)-4-(3-pyridyl)butanoate → Methyl 3-(3-Pyridylcarbonyl)but-3-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-oxo-3-(piperidylmethyl)-4-(3-pyridyl)butanoate | HCID 22457748 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | Methyl 3-(3-Pyridylcarbonyl)but-3-enoate | HCID 22457736 | 80.7% |
Reaction Steps
A solution of methyl 4-oxo-3-(piperidylmethyl)-4-(3-pyridyl)butanoate (4 g) in ethanol (10 mL) and 4N HCl/dioxane (4.0 mL) was heated at 80° C. for 12 hrs. The reaction mixture was concentrated and purified on flash chromatography (SIO2, CHCl3: MeOH: CH3COOH=10: 1:0.5) to give 2.28 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06399606B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-746d7d59bc1c4cefb1e9a593c263f6c0 |
| Source note | uspto-grants-2002_06 |