反应详情

1H-pyrazolo[3,4-c]pyridine-5-methanol (1.08 g, 7.27 mmol) was dissolved in DCM (120 mL) at rt, and DMSO (30 mL) and NEt3 (3.01 mL, 21.7 mmol) were added. After stirring for 10 min, SO3-pyridine (3.45 g, 13.45 mmol) was added. The mixture stirred at rt for ca. 1.5 hr, and quenched with sat. NH4Cl solution. The reaction mixture was extracted with DCM, washed with water and with brine, and dried with Na2SO4. The crude product was purified by a flash column to afford 1H-pyrazolo[3,4-c]pyridine-5-carboxaldehyde (220 mg, 21%).

1. stirringThe mixture stirred at rt for ca. 1.5 hr
2. customquenched with sat. NH4Cl solution
3. extractionThe reaction mixture was extracted with DCM
4. washwashed with water and with brine
5. dry with materialdried with Na2SO4
6. customThe crude product was purified by a flash column