Benzyl chloroformate → HCID 59894927, compound

HRID 2184738Notes

Reaction equation

C1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C@H:19]([C:36]([O:38][CH3:39])=[O:37])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[CH2:24][C:25]([OH:27])=[O:26])=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=CC=3)C=2C=CC=1.ClC(OCC1C=CC=CC=1)=O>>[CH3:39][O:38][C:36]([C@@H:19]([NH:18][C:16]([O:15][CH2:14][C:12]1[CH:11]=[CH:6][CH:7]=[CH:8][CH:13]=1)=[O:17])[CH2:20][S:21][CH2:22][CH:23]([C:28](=[O:35])[C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1)[CH2:24][C:25]([OH:27])=[O:26])=[O:37]

Participants

Reactant 2

HCID 10387Benzyl chloroformate

HCID 70109626HCID 70109626, compound

Product 1

HCID 59894927HCID 59894927, compoundYield 12%

Procedure

The title compound was prepared from 3-({(2R)-2-[(fluoren-9-ylmethoxy)carbonylamino]-2-(methoxycarbonyl)ethylthio}methyl)-4-oxo-4-(3-pyridyl)butanoic acid and benzyl chloroformate as described in Example 16 at 12% yield; ESMS, (M+1)+460.

Sources & evidence

ORD record: ord-1f16b1fba8c845ef9c6634f71130fb14
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399606B1

Reaction notes

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