Ethane, 2-bromo-1,1-diethoxy- → HCID 15888248, compound

HRID 2184768Notes

Reaction equation

HRID 2184768 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[N:19]=[C:18]([CH3:21])[N:17]=[C:16]([N:22]([CH2:27][CH3:28])[CH2:23][CH2:24][CH2:25][CH3:26])[C:15]=2[NH:14][C:13](=[NH:29])[CH2:12]1.[CH2:30](OC(OCC)CBr)[CH3:31]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[N:11]1[C:20]2[C:15](=[C:16]([N:22]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH3:28])[N:17]=[C:18]([CH3:21])[N:19]=2)[N:14]2[CH:30]=[CH:31][N:29]=[C:13]2[CH2:12]1

Participants

4

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 178449019HCID 178449019, compound

Product 1

HCID 15888248HCID 15888248, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the compound of Example 248 and a slight excess of bromoacetaldehyde diethyl acetal in ethanol is heated to reflux until the starting material is consumed. The reaction mixture is evaporated, and the residual material is purified by chromatography or recrystallization to afford the title product.

Workup

  1. temperatureto reflux until the starting material
  2. customis consumed
  3. customThe reaction mixture is evaporated
  4. customthe residual material is purified by chromatography or recrystallization

Sources & evidence

ORD record
ord-7ee06422a3214cfdbd43d51a8fc673a8
Source dataset
uspto-grants-2002_06
Patent number
US06399609B1

Reaction notes

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