Sulfuric Acid → HCID 135706125, compound

HRID 2184770Notes

Reaction equation

HRID 2184770 reaction equation
[C:1]([C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:13](=[O:14])[CH2:12][CH:11]([CH2:15][CH3:16])[C:10]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([OH:24])[CH:18]=3)=[N:9]2)=[CH:5][CH:4]=1)#N.[OH-:27].[Na+].S(=O)(=O)(O)[OH:30]>O>[C:1]([C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:13](=[O:14])[CH2:12][CH:11]([CH2:15][CH3:16])[C:10]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([OH:24])[CH:18]=3)=[N:9]2)=[CH:5][CH:4]=1)([OH:30])=[O:27]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 135706124HCID 135706124, compound

Product 1

HCID 135706125HCID 135706125, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

10 g of 2-(4-cyanobenzyl)-6-(3,4-dihydroxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one are added with stirring to a cooled solution of 1.2 g of NaOH in 100 ml of water and the mixture is subsequently stirred for 10 hours. It is warmed cautiously and a stream of air is passed through the solution. Cooled sulfuric acid and water are then added. The mixture is worked up in the customary manner and 2-(4-carboxybenzyl)-6-(3,4-dihydroxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one is obtained.

Workup

  1. temperatureIt is warmed cautiously

Sources & evidence

ORD record
ord-eb7eafd00f844db7ae5f7f4a42b11d31
Source dataset
uspto-grants-2002_06
Patent number
US06399611B1

Reaction notes

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