2-Acetylthiophene → beta-Dimethylamino-1-(2-thienyl)-2-propen-1-one

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Reaction Steps

A mixture of 2-acetylthiophene (10.0 g, 80 mmol) (Aldrich) and dimethylformamide dimethyl acetal (15 g, 126 mmol) is refluxed under nitrogen for 3 hrs, The reaction mixture is cooled and hexane (300 mL) added. The solid is collected by filtration to yield product (1) as an orange solid (9.1 g, 50 mmol, 63%).

Provenance & Evidence