反应详情

A mixture of 2-acetylthiophene (10.0 g, 80 mmol) (Aldrich) and dimethylformamide dimethyl acetal (15 g, 126 mmol) is refluxed under nitrogen for 3 hrs, The reaction mixture is cooled and hexane (300 mL) added. The solid is collected by filtration to yield product (1) as an orange solid (9.1 g, 50 mmol, 63%).

1. temperatureis refluxed under nitrogen for 3 hrs
2. temperatureThe reaction mixture is cooled
3. filtrationThe solid is collected by filtration