Water → 4-(Piperazin-1-yl)furo[3,2-c]pyridine

HRID 2184799Notes

Reaction equation

HRID 2184799 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.O.ClCCl>C(O)C>[N:11]1([C:2]2[C:7]3[CH:8]=[CH:9][O:10][C:6]=3[CH:5]=[CH:4][N:3]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

6

Reactant 4

HCID 962WaterHCID 4837PiperazineHCID 6344DichloromethaneHCID 27797464-Chlorofuro[3,2-c]pyridine

Product 1

HCID 27948084-(Piperazin-1-yl)furo[3,2-c]pyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.065 mol of 4-chlorofuro[3,2-c]pyridine and 5 equivalents of piperazine in 25 ml of ethanol is heated for 17 hours at 120° C. under an inert atmosphere. After cooling and concentration under reduced pressure, the residue obtained is stirred in the presence of 150 ml of water and 150 ml of dichloromethane. After decanting and extraction with dichloromethane, the organic phases are dried and filtered and then concentrated under reduced pressure, enabling the expected product to be isolated.

Workup

  1. temperatureAfter cooling
  2. concentrationconcentration under reduced pressure
  3. customthe residue obtained
  4. customAfter decanting
  5. extractionextraction with dichloromethane
  6. customthe organic phases are dried
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customto be isolated

Sources & evidence

ORD record
ord-332775058b384c42ad47dcff30773d1b
Source dataset
uspto-grants-2002_06
Patent number
US06399616B1

Reaction notes

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