反应详情

15 ml of a 2.9N ethanolic HCl solution are added to a solution of 0.9 g of the compound obtained in Step 3 in 15 ml of ethanol. The reaction mixture is stirred for 24 hours at ambient temperature and then concentrated in vacuo, enabling the expected product to be isolated in dihydrochloride form. The dihydrochloride is converted into a free base by extraction in dichloromethane in the presence of water that has previously been adjusted to a basic pH by 20% sodium hydroxide solution.

1. concentrationconcentrated in vacuo
2. customto be isolated in dihydrochloride form
3. extractionThe dihydrochloride is converted into a free base by extraction in dichloromethane in the presence of water that