2-Aminobenzonitrile → N-(2-cyanophenyl)cyclohexanecarboxamide

HRID 2184837Notes

Reaction equation

HRID 2184837 reaction equation
F[C:2](F)(F)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11].C(C1C=CC=CC=1N)#[N:21]>>[C:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=[O:11])#[N:21]

Participants

3

Reactant 2

HCID 729132-AminobenzonitrileHCID 1367212N-[2-(trifluoromethyl)phenyl]cyclohexanecarboxamide

Product 1

HCID 724309N-(2-cyanophenyl)cyclohexanecarboxamideYield 75%

Procedure

This compound was prepared following the procedure described for compound 26A in example 26, except that 2-cyanoaniline was used in place of 2-trifluoromethylaniline. Yield 75%. M.p. 135-137° C.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0654ae5f8d8e40b8bd6cce858f9e542d
Source dataset
uspto-grants-2002_06
Patent number
US06399614B1

Reaction notes

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