Thionyl Chloride → Pyrimidine-2-carbonyl chloride

HRID 2184844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2184844
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[C:8]([OH:10])=O.S(Cl)([Cl:13])=O>C(Cl)(Cl)Cl>[N:2]1[CH:7]=[CH:6][CH:5]=[N:4][C:3]=1[C:8]([Cl:13])=[O:10]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 54594277Pyrimidine-2-carboxylic acid hydrochloride

Produkt 1

HCID 18403666Pyrimidine-2-carbonyl chlorideAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A stirred mixture of 0.837 g of 2-pyrimidinecarboxylic acid hydrochloride (prepared as described in S. Gronowitz et al. Ark. Chem, 1964, 22, 66-82), 30 mL of CHCl3 and 2 mL of thionyl chloride was heated at reflux for 12 h. After cooling to r.t., the suspension was filtered and the filtrate was evaporated to dryness in vacuo to afford 0.306 g (67%) of the title compound as a green solid used in the next step without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 12 h
  3. filtrationthe suspension was filtered
  4. customthe filtrate was evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bb4e96babe1c46cda69290e79d07af90
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399614B1

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